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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: J Nanotheranostics. 2022 Sep 30;3(4):177–188. doi: 10.3390/jnt3040012

Figure 3. CTX-INX-GNP combined with standard of care chemotherapy and radiotherapy inhibited tumor growth and prolonged survival of mice with orthotopic glioblastoma.

Figure 3

(A) In mice bearing orthotopic glioblastoma tumors, treatment combining CTX-INS-GNP with TMZ and RT significantly inhibited tumor growth up to six weeks after treatment, as compared to untreated mice or mice treated with TMZ + RT. Two-way ANOVA with repeated measures showed a main effect of group (F(2,19) = 4.37; p < 0.028). Results presented as mean ±SEM. (B) Kaplan-Meier survival curve of mice with orthotopic glioblastoma. Addition of CTX-INS-GNPs to standard of care therapy significantly increased median survival (p = 0.043, Kaplan-Meier log-rank test) as compared to untreated controls and standard-of-care (RT + TMZ) treated mice.