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. Author manuscript; available in PMC: 2022 Oct 27.
Published in final edited form as: Nature. 2022 Sep 15:10.1038/s41586-022-05319-3. doi: 10.1038/s41586-022-05319-3

Extended Data Figure 4. Twisted and untwisted filaments in 2D class averages and projections.

Extended Data Figure 4

(a,c,e,g), 2D class averages without twist for case 1 of PDD; (b,d,f,h) projections of untwisted models with the Lewy fold, rotated by 0, 220, 110 and 310 degrees, respectively, along the first Euler angle (rot). Box size, 640 Å. (i-p) Projections of untwisted models of the type 3 filaments from seeded assembly with MSA brain (EMD-12269, PDB 7NCK), rotated by 0, 22.5, 45, 67.5, 90, 112.5, 135 and 157.5 degrees, respectively. (q-x) Projections of untwisted models with the MSA type IIA fold (EMD-10651, PDB 6XYP), rotated by 0, 22.5, 45, 67.5, 90, 112.5, 135 and 157.5 degrees, respectively.