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. Author manuscript; available in PMC: 2022 Oct 27.
Published in final edited form as: ACS Nano. 2019 Oct 15;13(11):12591–12598. doi: 10.1021/acsnano.9b03473

Figure 3. Iterative refinement of DNA origami structures through placement of internal supports.

Figure 3

a. A structure is designed with internal supports, mutant structures are then generating by reconnecting one end of an internal support. These mutant structures are then individually simulated and scored and mutations are incorporated to the next generation either through gradient descent or simulated annealing. b. The performance of a rod structure is evaluated by the amount of fluctuation in the overall end-to-end distance. c.) Renderings of a 13-unit rod before (top) and after (bottom) 23 iterations of simulate annealing-based refinement, internal supports are highlighted in red. d. End-to-end fluctuations of the rod structure in a simulation, before and after refinement.