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. Author manuscript; available in PMC: 2023 Apr 24.
Published in final edited form as: Nat Neurosci. 2022 Oct 24;25(11):1505–1518. doi: 10.1038/s41593-022-01179-2

Extended Data Figure 5. Characterization of the role of social dominance and affective sensitivity in social decision-making.

Extended Data Figure 5

a, Number of altruistic and selfish choices in subordinate (two-way RM ANOVA, choice (altruistic, selfish) x time (days), F(4, 152)=4.92, p=0.0009, n=19), and dominant actor mice (F(4, 144)=3.26, p=0.0122, n=20). b, Dominant actor mice grouped by altruistic (two-way RM ANOVA, choice (altruistic, selfish) x time (days), F(4, 96)=8.83, p<0.0001, n=13) and selfish preference (two-way RM ANOVA, choice (altruistic, selfish) x time (days), F(4, 48)=10.45, p<0.0001, n=7) on the SDM task. c, Subordinate actor mice grouped by altruistic (two-way RM ANOVA, choice (altruistic, selfish) x time (days), F(4, 48)=3.09, p<0.0001, n=7) and selfish preference (two-way RM ANOVA, choice (altruistic, selfish) x time (days), F(4, 88)=12.52, p<0.0001, n=12) on the SDM task. d-e, Social dominance (normalized David’s Score) quantified based on the number and directionality of interactions in the tube test in actor and recipient mice grouped by selfish (d, two-tailed paired t-test: t=3.17, d.f.=34, p=0.0032; n=18) and altruistic (e, two-tailed paired t-test: t=0.79, d.f.=38, p=0.4324; n=20) actors and respective recipient conspecific. f-g, Normalized David’s Score in actor mice grouped by altruistic (f) or selfish (g) preference and by their social rank in relation to the normalized David’s Score of their respective recipient. h, Decision preference score in actor mice grouped by social rank (α: n=8, β: n=9, γ: n=12, δ: n=8; one-way ANOVA, F(3, 33)=3.90, p=0.0172; two-tailed unpaired t-test, α vs. β: t=2.12, d.f.=15, p=0.050; α vs. γ: t=2.87, d.f.=18, p=0.0100; α vs. δ: t=2.26, d.f.=14, p=0.7982; δ vs. γ: t=2.42, d.f.=18, p=0.0261). i, Top, Schematic representation of the observational fear learning and freezing behavior in actor mice, grouped by altruistic (n=6) or selfish (n=7) preference during baseline (two-tailed unpaired t-test: t=15.31, d.f.=13, p=0.1497). Bottom, freezing behavior (conditioning-baseline) in altruistic and selfish actors (two-tailed unpaired t-test: t=3.30, d.f.=13, p=0.0057) and total time spent in the proximity of the divider between the actor and recipient compartment (two-tailed paired t-test: t=0.39, d.f.=13, p=0.7021). j, Social dominance (normalized David’s score) predicts affective sensitivity (freezing behavior during observational fear learning) (linear regression, n=27 mice, y=8.971x+15.61, F(1, 25)=4.47, p=0.0446). *p<0.05, **p<0.01, ***p<0.001. n.s. not significant. Values are expressed as mean ± s.e.m.