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Schematic overview of intracellular lipolysis, the sequential breakdown of TG to glycerol and three molecules of FAs. ATGL catalyzes the hydrolysis of TG stored in LDs to DG and FA, which is the first step of lipolysis. The next step of lipolysis is catalyzed by HSL to degrade DGs to MGs and FAs. The last step of lipolysis is catalyzed by MGL, which hydrolyzes MG to glycerol and FA.
