. Author manuscript; available in PMC: 2022 Nov 14.

Published in final edited form as: Curr Opin Physiol. 2019 May 2;11:29–34. doi: 10.1016/j.cophys.2019.04.014

Table 1. The effect of ablating specific sub-populations of peripheral sensory neurons on nocifensive behaviours in mice.

The targeted neuronal population is shown along with the method of ablation (capsaicin treatment − experimenter controlled; diphtheria toxin fragment A (DTA) − genetically controlled; diphtheria toxin receptor activation (DTR) − experimenter controlled). Changes in nocifensive phenotype to noxious heat, mechanical (Mech.) and cold are shown (deficit: red; no change/normal: green; not studied: grey)

Neuronal population	Ablation type	Nocifensive behaviour			Reference
Neuronal population	Ablation type	Heat	Mech.	Cold	Reference
Trpv1	Capsaicin				Cavanaugh et al., 2009
Trpv1	DTA				Mishra et al., 2011
Trpv1	DTR				Pogorzala et al., 2013
Mrgprd	DTR				Pogorzala et al., 2013
Mrgprd	DTR				Cavanaugh et al., 2009
Trpm8	DTR				Pogorzala et al., 2013
Trpm8	DTR				Knowlton et al., 2013
Trpa1	DTR				Yarmolinsky et at., 2016
CGRP	DTR				McCoy et al., 2013
Na_V1.8	DTA				Abrahamsen et al., 2008

Inline graphic Deficit; Normal; Not studied.