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. Author manuscript; available in PMC: 2022 Nov 14.
Published in final edited form as: Neurobiol Aging. 2022 Sep 22;121:1–14. doi: 10.1016/j.neurobiolaging.2022.09.006

Table 2.

Table of unique and shared effects for three models corresponding to statistically significant clusters of interest at TFCE-level. Each TFCE-cluster is represented by its name according to AAL atlas and coordinates in MNI space. Unique effects included effects of i) Age, ii) CBF and iii) Performance. Common effects included shared signals between i) age and CBF (Age,CBF) , ii) age and performance (Age,Performance), iii) CBF and performance (CBF,Performance), and iv) age, CBF and performance (Age,CBF,Perfomance). In Model 1, Cattell activity was the dependent variable, while age, CBF and performance were dependent variables, and education and sex were covariates of no interest. Model 2 is the same as Model 1, but with anti-hypertensive medications added as covariate of no interest. Model 3 is the same as Model 1, but with educational attainment added as covariate of no interest. Significance was determined based on a null distribution of 5.000 permutations. Effects at p-value < 0.05 shown in bold font.

Cluster Name Contrast Name Model 1 Model 2 Model 3
T-score p-value T-score p-value T-scare p-value
R. Thalamus [6, 12,12] Age -0.37 0.356 -0.25 0.400 -0.31 0.379
CBF 1.49 0.069 1.49 0.069 1.57 0.059
Performance 3.32 <0.001 3.31 <0.001 3.03 <0.001
Age,CBF 0.86 0.197 0.73 0.232 0.86 0.196
Age,Performance 3.13 <0.001 2.57 0.005 2.56 0.006
CBF,Performance 0.72 0.237 0.72 0.236 0.91 0.183
Age,CBF,Performance 3.11 <0.001 2.48 0.007 2.94 0.002
L. Precuneus [-3, -66,30] Age 3.50 <0.001 3.19 <0.001 3.49 <0.001
CBF -1.65 0.051 -1.64 0.051 -1.64 0.052
Performance -1.81 0.036 -1.80 0.036 -1.76 0.040
Age,CBF 1.98 0.025 1.83 0.035 1.99 0.024
Age,Performance 5.38 <0.001 4.35 <0.001 4.92 <0.001
CBF,Performance 0.41 0.343 0.41 0.342 0.52 0.302
Age,CBF,Performance 3.24 <0.001 2.52 0.006 3.15 <0.001
L. Superior Parietal Lobule [-21, -63,42] Age -4.64 0.000 -4.53 <0.001 -4.66 <0.001
CBF 0.70 0.243 0.67 0.251 0.69 0.245
Performance 3.07 <0.001 3.08 0.001 3.19 <0.001
Age,CBF 1.31 0.096 1.27 0.103 1.31 0.097
Age,Performance 8.24 <0.001 6.80 <0.001 7.85 <0.001
CBF,Performance 0.77 0.222 0.76 0.225 0.77 0.220
Age,CBF,Performance 3.72 <0.001 3.01 <0.001 3.48 <0.001
L. Middle Occipital Gyrus [-21, -87,0] Age -4.31 <0.001 -4.14 <0.001 -4.32 <0.001
CBF 2.24 0.013 2.19 0.015 2.26 0.013
Performance 0.77 0.221 0.77 0.220 0.91 0.183
Age,CBF 2.95 0.002 2.85 0.002 2.95 0.002
Age,Performance 4.93 <0.001 4.05 <0.001 4.82 <0.001
CBF,Performance -0.37 0.355 -0.37 0.357 -0.44 0.331
Age,CBF,Performance 3.25 <0.001 2.58 0.005 2.99 0.002
L. Middle Cingulate Cortex [-12, -45, 30] Age 3.67 <0.001 3.31 0.001 3.64 <0.001
CBF 1.94 0.027 -1.94 0.027 1.96 0.026
Performance -1.89 0.030 -1.89 0.030 -1.77 0.039
Age,CBF 2.09 0.019 1.96 0.026 2.11 0.018
Age,Performance 5.86 <0.001 4.66 <0.001 5.22 <0.001
CBF,Performance -0.31 0.378 -0.30 0.381 0.23 0.409
Age,CBF,Performance 2.96 0.002 2.34 0.010 2.93 0.002