Figure 5.

Absolute benefits and harms of SGLT2 inhibition per 1000 patient-years by diabetes status and patient group

Patient group specific absolute effects estimated by applying the diabetes subgroup specific RR to the average event rate in the placebo arms (first event only). Negative numbers indicate events avoided by SGLT2 inhibition per 1000 patient-years. Error bars represent SE in the numbers of events avoided or caused, estimated from uncertainty in the RRs. Mean eGFR values are given for combined trial populations by patient group and diabetes status. Placebo population mean event rates are the absolute numbers of events per 1000 patient-years in the placebo groups of all trials in the relevant subpopulation. eGFR=estimated glomerular filtration rate. RR=relative risk. SGLT2i=sodium glucose co-transporter-2 inhibitor. *Additionally, two (SE 0·5) fewer myocardial infarctions per 1000 patient-years of SGLT2i treatment were observed in the diabetes and high atherosclerotic cardiovascular risk group. †RRs to determine absolute effects for lower limb amputation included CANVAS. ‡Too few ketoacidosis events to estimate absolute effects.