Table 1. Information on outcome data sources.
| Data source | Cardiovascular disease | Cases | Controls | Population | Covariates adjusted in GWAS |
|---|---|---|---|---|---|
| GWAS meta-analysis (Nielsen et al.) | Atrial fibrillation | 60 620 | 970 216 | European | Birth year, sex, genotype batch, and 1-4 principal components |
| CARDIoGRAMplusC4D plus UKBB | Coronary artery disease | 122 733 | 424 528 | Mixed | NA |
| HERMES consortium | Heart failure | 47 309 | 930 014 | European | Age and sex, and principal components in individual studies where applicable |
| MEGASTROKE consortium | Stroke | 40 585 | 406 111 | European | Age and sex |
| Ischaemic stroke | 34 217 | NA | |||
| Large artery stroke | 3373 | 406 111 | |||
| Small vessel stroke | 5386 | 406 111 | |||
| Cardioembolic stroke | 7193 | 406 111 | |||
| ISGC | Intracerebral hemorrhage | 3223 | 3725 | European | Age, sex, and principal components |
| The UK Biobank study (UKBB) | Aortic aneurysm | 2261 | 365 300 | European | Age, sex, and 10 genetic principal components |
| Aortic valve stenosis | 3528 | 364 033 | |||
| Stroke | 12 036 | 355 525 | |||
| Intracerebral hemorrhage | 1504 | 366 057 | |||
| Subarachnoid hemorrhage | 1292 | 366 269 | |||
| Ischaemic stroke | 6566 | 360 995 | |||
| Transient ischaemic attack | 4813 | 362 748 | |||
| Venous thromboembolism | 16 412 | 351 149 | |||
| Peripheral vessel disease | 4593 | 362 968 | |||
| The FinnGen consortium | Aortic aneurysm | 1919 | 167 843 | European | Age, sex, the first 10 genetic principal components, and genotyping batch |
| Atrial fibrillation | 17 325 | 97 214 | |||
| Coronary artery disease | 16 631 | 160 268 | |||
| Heart failure | 9576 | 159 286 | |||
| Stroke | 14 171 | 133 027 | |||
| Intracerebral hemorrhage | 1224 | 163 533 | |||
| Subarachnoid hemorrhage | 1019 | 163 508 | |||
| Ischaemic stroke | 8046 | 164 286 | |||
| Transient ischaemic attack | 6729 | 164 286 | |||
| Venous thromboembolism | 6913 | 169 986 | |||
| Peripheral vessel disease | 5323 | 167 843 |
CARDIoGRAMplusC4D, Coronary ARtery DIsease Genome-wide Replication and Meta-analysis plus The Coronary Artery Disease Genetics; GWAS, genome-wide association study; HERMES; Heart Failure Molecular Epidemiology for Therapeutic Targets; ISGC, International Stroke Genetic Consortium; NA, not available. The UK Biobank was included in Consortium (Nielsen et al.), HERMES consortium, and ISGC.