TABLE 3.
Results of multivariable MR analysis with adjustment for sleep duration, short sleep, insomnia and BMI in the meta‐analysis of UK Biobank and FinnGen
| Cancer | Model | OR | 95% CI | P value |
|---|---|---|---|---|
| Digestive tract cancer | Univariable MR | 0.94 | 0.90‐0.98 | .007 |
| MVMR adjusted for sleep duration | 0.94 | 0.90‐0.98 | .009 | |
| MVMR adjusted for short sleep | 0.94 | 0.90‐0.99 | .010 | |
| MVMR adjusted for insomnia | 0.94 | 0.90‐0.98 | .008 | |
| MVMR adjusted for BMI | 0.94 | 0.90‐0.98 | .008 | |
| Stomach cancer | Univariable MR | 0.84 | 0.73‐0.97 | .014 |
| MVMR adjusted for sleep duration | 0.84 | 0.74‐0.97 | .015 | |
| MVMR adjusted for short sleep | 0.84 | 0.73‐0.97 | .015 | |
| MVMR adjusted for insomnia | 0.84 | 0.73‐0.96 | .013 | |
| MVMR adjusted for BMI | 0.84 | 0.73‐0.96 | .013 | |
| Colorectal cancer | Univariable MR | 0.92 | 0.87‐0.98 | .009 |
| MVMR adjusted for sleep duration | 0.93 | 0.87‐0.98 | .013 | |
| MVMR adjusted for short sleep | 0.93 | 0.87‐0.98 | .013 | |
| MVMR adjusted for insomnia | 0.92 | 0.87‐0.98 | .012 | |
| MVMR adjusted for BMI | 0.93 | 0.87‐0.98 | .012 |
Abbreviations: BMI, body mass index; CI, confidence interval; MR, Mendelian randomization; MVMR, multivariable Mendelian randomization; OR, odds ratio.