Table 2. Binding affinities (KD in nM) of BMP/BMPR interactions.
Tables summarizing the KD (nM) of the BMP/BMPR interactions for: A) type I and B) type II receptors, obtained from the kinetic experiments in a conformation where the BMPR is immobilized. The interactions between BMP-9/ALK3 and BMP-9/ALK6 yielded a very low signal (N.A). The high affinity couples are colored in dark blue. The error values represent the s.d (n=3).
| BMP\BMPR | ALK1 | ALK2 (ACTR-I) |
ALK3 (BMPR-IA) |
ALK5 (TGFβR-I) |
ALK6 (BMPR-IB) |
|---|---|---|---|---|---|
| BMP-2 | 13.0 ± 1.6 | 7.0 ± 2.3 | 0.21 ± 0.03 | 5.8 ± 1.1 | 0.5 ± 0.1 |
| BMP-4 | 55.4 ± 4.0 | 10.5 ± 3.8 | 1.7 ± 0.5 | 21.9 ± 6.6 | 3.1 ± 0.3 |
| BMP-7 | 23.1 ± 2.1 | 18.4 ± 3.8 | 19.0 ± 2.1 | 22.6 ± 1.1 | 15.0 ± 1.2 |
| BMP-9 | 0.2 ± 0.1 | 133.1 ± 35.1 | N.A | 51.0 ± 18.3 | N.A |
| BMP\BMPR | BMPR-II | ACTR-IIA | ACTR-IIB |
|---|---|---|---|
| BMP-2 | 5.4 ± 0.8 | 6.1 ± 1.2 | 6.3 ± 3.4 |
| BMP-4 | 56.0 ± 6.0 | 21.4 ± 3.7 | 26.0 ± 0.5 |
| BMP-7 | 5.5 ± 1.2 | 1.3 ± 0.3 | 7.1 ± 0.7 |
| BMP-9 | 0.8 ± 0.2 | 1.7 ± 0.1 | 1.4 ± 0.4 |