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. Author manuscript; available in PMC: 2022 Dec 30.
Published in final edited form as: Biointerphases. 2021 Jun 8;16(3):031001. doi: 10.1116/6.0000926

Table 3. Binding affinities (KD) (nM) of BMP/BMPR-I/BMPR-II interactions.

Table summarizing the KD1 and KD2 (nM) of the BMP/BMPR-I/BMPR-II interactions obtained from the kinetic experiments in a conformation where ALK2 and type-II BMPR are loaded sequentially. The error values represent the s.d (n=3).

  ALK2 (ACTR-I)  
KD (nM) BMPR-II ACTR-IIA ACTR-IIB
KD1 KD2 KD1 KD2 KD1 KD2
BMP-2 17.8 ± 7.2 33.0 ± 10.2 31.7 ± 6.5 47.8 ± 4.5 14.4 ± 2.3 46.1 ± 11.4
BMP-4 55.8 ± 17.2 90.7 ± 33.3 14.1 ± 2.5 125.0 ± 20.4 88.7 ± 22.6 103.2 ± 39.0
BMP-7 4.6 ± 0.7 19.1 ± 6.4 7.1 ± 1.8 350.6 ± 12.3 19.1 ± 5.5 60.7 ± 22.9