TABLE 1.
Demographics, clinical features and outcome of DILI patients and non‐DILI acute liver injury controls
| DILI cases (n = 246) | Non‐DILI acute liver injury controls (n = 100) | p value | |
|---|---|---|---|
| Age (years), mean ± SD | 56 ± 18 | 54 ± 18 | .339 |
| Female, n (%) | 141 (57%) | 52 (52%) | .433 |
| Asymptomatic, n (%) | 47 (20%) | 13 (13%) | .212 |
| Type of liver injury, n (%) | .094 | ||
| Hepatocellular | 139 (62%) | 70 (75%) | |
| Cholestatic | 42 (19%) | 12 (13%) | |
| Mixed | 44 (20%) | 12 (13%) | |
| Jaundice, n (%) | 141 (60%) | 73 (75%) | .011 |
| Pruritus, n (%) | 81 (34%) | 18 (19%) | .006 |
| Eosinophilia, n (%) | 24 (10%) | 5 (5.2%) | .207 |
| Body mass index, mean ± SD | 26 ± 5.0 | 27 ± 5.8 | .297 |
| Diabetes mellitus type II, n (%) | 21 (9.0%) | 8 (8.3%) | 1.000 |
| Dyslipidaemia, n (%) | 41 (18%) | 16 (17%) | .966 |
| Smoking, n (%) | 26 (11%) | 21 (22%) | .019 |
| Hospitalization, n (%) | 169 (70%) | 78 (80%) | .073 |
| Severity, n (%) | .001 | ||
| Mild | 95 (43%) | 21 (22%) | |
| Moderate | 101 (45%) | 51 (54%) | |
| Severe | 18 (8.1%) | 16 (17%) | |
| Fatal/liver transplantation | 9 (4.0%) | 7 (7.4%) | |
| Acute liver failure and recovery, n (%) | 6 (2.4%) | 2 (2.1%) | 1.000 |
| Liver‐related death within 6 months, n (%) | 3 (1.2%) | 3 (3.1%) | .359 |
| Liver transplantation, n (%) | 6 (2.5%) | 4 (4.2%) | .481 |
| Non‐liver‐related death within 6 months, n (%) | 3 (1.2%) | 2 (2.1%) | .627 |
Note: Percentages are based on number of available observations.