TABLE 2.
Demographics, clinical features and outcome in the acute non‐DILI acute liver injury controls
| Acute viral hepatitis (n = 34) | Autoimmune hepatitis (n = 41) | Acute biliary obstruction (n = 13) | Other diagnoses a (n = 12) | p value | |
|---|---|---|---|---|---|
| Age (years), mean ± SD | 46 ± 16 | 58 ± 16 | 57 ± 21 | 58 ± 20 | .015 |
| Female, n (%) | 12 (35%) | 26 (63%) | 7 (54%) | 7 (58%) | .104 |
| Asymptomatic, n (%) | 5 (16%) | 6 (15%) | 2 (15%) | 0 (0%) | .684 |
| Type of liver injury, n (%) | <.001 | ||||
| Hepatocellular | 22 (69%) | 38 (97%) | 5 (42%) | 5 (45%) | |
| Cholestatic | 4 (13%) | 1 (3.0%) | 2 (17%) | 5 (45%) | |
| Mixed | 6 (19%) | 0 (0%) | 5 (42%) | 1 (9.1%) | |
| Jaundice, n (%) | 20 (63%) | 37 (90%) | 8 (62%) | 8 (73%) | .017 |
| Pruritus, n (%) | 6 (19%) | 5 (12%) | 3 (23%) | 4 (36%) | .287 |
| Eosinophilia, n (%) | 0 (0%) | 2 (4.9%) | 0 (0%) | 3 (27%) | .011 |
| Body mass index, mean ± SD | 25 ± 3.6 | 28 ± 6.5 | 28 ± 6.1 | 24 ± 5.6 | .107 |
| Diabetes mellitus type II, n (%) | 3 (9.7%) | 2 (5.0%) | 2 (15%) | 1 (8.3%) | .562 |
| Dyslipidaemia, n (%) | 3 (9.7%) | 10 (25%) | 2 (15%) | 1 (8.3%) | .349 |
| Smoking, n (%) | 9 (29%) | 8 (20%) | 1 (7.7%) | 3 (25%) | .467 |
| Hospitalization, n (%) | 21 (66%) | 38 (93%) | 10 (83%) | 9 (75%) | .024 |
| Severity, n (%) | .236 | ||||
| Mild | 8 (26%) | 5 (13%) | 4 (33%) | 4 (33%) | |
| Moderate | 18 (58%) | 22 (55%) | 7 (58%) | 4 (33%) | |
| Severe | 4 (13%) | 7 (18%) | 1 (8.3%) | 4 (33%) | |
| Fatal/liver transplantation | 1 (3.2%) | 6 (15%) | 0 (0%) | 0 (0%) | |
| Liver‐related death within 6 months, n (%) | 0 (0%) | 3 (7.7%) | 0 (0%) | 0 (0%) | .415 |
| Liver transplantation, n (%) | 1 (3.2%) | 3 (7.7%) | 0 (0%) | 0 (0%) | .798 |
| Non‐liver‐related death within 6 months, n (%) | 0 (0%) | 0 (0%) | 1 (7.7%) | 1 (8.3%) | .067 |
Note: Percentages are based on number of available observations.
a
Patients with acute cholestasis, bacterial infection, cholangiocarcinoma, ischaemic hepatitis and pancreatic cancer.