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. Author manuscript; available in PMC: 2023 Oct 1.
Published in final edited form as: Mol Cell. 2022 Sep 13;82(19):3598–3612.e7. doi: 10.1016/j.molcel.2022.08.019

Figure 4. SWI/SNF maintains enhancer accessibility and activity.

Figure 4

A) Nucleosome occupancy changes after Snr1 depletion. Scaled MNase-seq coverage of Snr1-AID cell lines 12 hours after auxin (pink) or mock (black) treatment. Mean coverage of 2 replicates shown per sample, centered on developmental and housekeeping TSSs or enhancer centers. B) Genome browser tracks of mixed-library STARRseq coverage in Parental S2 cells (brown), and Snr1-AID cells before (grey) and after (pink) Snr1 depletion. Below: housekeeping and developmental enhancer activities in S2 cells, with a developmental-specific enhancer highlighted by grey shading.C) Changes in housekeeping and developmental enhancer activity after SWI/SNF depletion. Boxplots of log2 fold-change in enhancer activity as measured by STARR-seq after auxin treatment in parental, Brd7-AID, or Snr1-AID cells (** p < 2.2x10-16 Wilcoxon-test).