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. Author manuscript; available in PMC: 2023 Oct 1.
Published in final edited form as: Mol Cell. 2022 Sep 13;82(19):3598–3612.e7. doi: 10.1016/j.molcel.2022.08.019

Figure 6. Nucleosome affinity profiles reflect remodeler dependencies.

Figure 6

A) Predicted nucleosome occupancy scores for housekeeping and developmental promoters (red), compared to negative regions (grey). B) Nucleosome affinity and accessibility for active vs. inactive cell-type-specific enhancers. Top: Nucleosome affinity scores for S2-cell specific (left) and BG3 specific (right) developmental enhancers (red) and negative regions (grey). Bottom: MNase-seq coverage profiles in S2 cells at the same regions (blue), compared to negative regions (grey). C) Model of remodeler activity and dependencies at enhancers and promoters. Red-to-black gradient depicts nucleosome favorability of DNA sequence, where red is less favorable and black is more favorable.