Extended Data Fig. 4. Hole formation around defects from experiments.
(a) Averaged number of defects on soft and stiff gels obtained from n2.3kPa = 6 circles for soft (2.3kPa) gels and n55kPa= 5 circles for stiff (55kPa) gels. (b) Average velocity flow field around +1/2 defects demonstrating the extensile nature of MDCK monolayers on soft (2.3kPa) gels (n=2646 defects) and stiff (30kPa) gels (n=2765 defects) obtained from experiments. (c) MSD of +1/2 and -1/2 defects on both soft and stiff gels (n=15 defects for -1/2 defects and +1/2 defects on 55kPa and n=17 defects for +1/2 defects on 2.3kPa gels). (d) Lifetime of random tensile regions on both soft (2.3kPa) and stiff (30kPa) regions obtained from TFM for n=30 regions (****p < 0.0001)