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. Author manuscript; available in PMC: 2023 Jan 30.
Published in final edited form as: Rev Physiol Biochem Pharmacol. 2020 Aug 1;185:195–231. doi: 10.1007/112_2020_25

Fig. 2. Acidic endosomal pH promotes Alzheimer’s disease pathology.

Fig. 2

Pathological endosomal acidification promotes amyloid pathology at all key steps of amyloidogenesis, including cleavage of APP to produce Aβ, monomer aggregation, and oligomer deposition, culminating in plaques complexed with metal ions. APP amyloid precursor protein, BACE1 β-secretase, GSC gamma secretase complex, SORL1 Sortilin Related Receptor 1, Aβ amyloid β