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. 2022 Jul 15;52(1):58–70. doi: 10.1093/ije/dyac143

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© The Author(s) 2022; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)

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Independent effects of genetically predicted obesity-related traits on the risk of breast cancer after adjusting for each confounder separately and together using multivariable Mendelian randomization

The y-axis details the genetically predicted confounder(s) for which adjustment was made and the x-axis details the odds ratios and 95% confidence intervals per 1-standard deviation increase in exposure. Asterisks (*) denote the tests survived false discovery rate (FDR) correction (P_FDR < 0.05). Total effect refers to the estimate derived from univariable Mendelian randomization.

BMI, body mass index; WHR, waist-to-hip ratio; WHR_adjBMI, waist-to-hip ratio adjusted for body mass index; ER, oestrogen receptor; AAM, age at menarche; ANM, age at natural menopause; OR, odds ratio.