Table 2.
Independent effect of adult obesity and childhood obesity on the risk of breast cancer using multivariable Mendelian randomization analysis
| BC overall |
ER+ |
ER– |
||||
|---|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |
| Model 1 | ||||||
| BMI | 1.00 (0.90–1.10) | 0.96 | 0.99 (0.88–1.11) | 0.88 | 0.96 (0.82–1.12) | 0.58 |
| Childhood BMI | 0.84 (0.77–0.93) | 3.93 × 10–4* | 0.86 (0.77–0.95) | 4.05 × 10–3* | 0.83 (0.72–0.96) | 1.43 × 10–2* |
| Model 2 | ||||||
| WHR | 0.90 (0.82–0.98) | 1.49 × 10–2* | 0.90 (0.81–1.00) | 4.29 × 10–2 | 0.93 (0.84–1.04) | 0.20 |
| Childhood BMI | 0.84 (0.76–0.91) | 6.57 × 10–5* | 0.86 (0.78–0.95) | 2.87 × 10–3* | 0.76 (0.68–0.85) | 6.10 × 10–7* |
| Model 3 | ||||||
| WHRadjBMI | 0.92 (0.86–0.99) | 1.98 × 10–2* | 0.91 (0.84–0.98) | 1.92 × 10–2* | 0.96 (0.88–1.05) | 0.35 |
| Childhood BMI | 0.80 (0.74–0.87) | 1.24 × 10–7* | 0.82 (0.75–0.90) | 3.40 × 10–5* | 0.74 (0.67–0.82) | 6.09 × 10–9* |
Model 1: independent effect of adult BMI and childhood BMI on BC; Model 2: independent effect of adult WHR and childhood BMI on BC; Model 3: independent effect of adult WHRadjBMI and childhood BMI on BC. Asterisks (*) denote the tests survived false discovery rate (FDR) correction (PFDR < 0.05).
BMI, body mass index; WHR, waist-to-hip ratio; WHRadjBMI, waist-to-hip ratio adjusted for body mass index; BC, breast cancer; ER, oestrogen receptor; OR, odds ratio.