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. Author manuscript; available in PMC: 2023 Feb 24.
Published in final edited form as: Addict Biol. 2021 Oct 12;27(1):e13100. doi: 10.1111/adb.13100

Figure 5. Two-sample Mendelian randomisation analysis shows no evidence for causal effect of alcohol consumption on measures of epigenetic age acceleration.

Figure 5

(A) AgeAccelGrim and (B) AgeAccelPheno. Data on the genetic association with alcohol use (AUDIT-C) were extracted from Kranzler et al.22 Summary statistics for these SNPs were extracted from GWASs for AgeAccelGrim and AgeAccelPheno conducted by McCartney et al.21 rs185177474 was not available in AgeAccelGrim and AgeAccelPheno summary statistics; thus, rs151242810 was used as a proxy (R2 = 0.976; see Section 2). CI, confidence interval; N SNP, number of SNPs included in the MR analysis