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. Author manuscript; available in PMC: 2023 Mar 6.
Published in final edited form as: Leukemia. 2022 May 26;36(8):1969–1979. doi: 10.1038/s41375-022-01601-5

Figure 7. Mesenchymal stromal cells control leukemic cell’s energy metabolism through CXCL12 production.

Figure 7

(A) Oxygen consumption rate (OCR) indicates mitochondrial respiration after oligomycin, FCCP and Rot/AA treatment in LSCs-enriched (Lin-, CD45.1+)cells from Prx1-Cxcl12-Mut and Prx1-Cxcl12-Ctrl mice. (B,C) Seahorse measurement of: (B) ATP production and (C) glycolysis, extracellular acidification rate (ECAR) in LSCs-enriched cells from Prx1-Cxcl12-Mut and Prx1-Cxcl12-Ctrl mice. Data are representative of at least 3 independent experiments; n= 6 mice per genotype per experiment unless otherwise stated. Data are represented as mean and SD. * P< .05; ** P< .01; *** P< .001.