. Author manuscript; available in PMC: 2023 Mar 13.

Published in final edited form as: Nat Rev Mol Cell Biol. 2021 Sep 30;23(2):93–106. doi: 10.1038/s41580-021-00417-y

Table 1. Major eukaryotic deadenylases.

Complex	Subunit name			Function
Complex	H. sapiens	S. cerevisiae	S. pombe	Function
Pan2-Pan3	PAN2	Pan2		DEDD exonuclease
Pan2-Pan3	PAN3	Pan3		RNA binding, scaffold
Ccr4-Not	CNOT1	Not1	Not1	Scaffold
	CNOT2	Not2	Not2	NOT box scaffold
	CNOT3	Not3, Not5	Not3	NOT box scaffold
	(CNOT4)	Not4	Mot2	RING E3 ligase
	CNOT6/6L	Ccr4	Ccr4	EEP exonuclease
	CNOT7/8	Pop2	Caf1	DEDD exonuclease
	CNOT9	Caf40	Rcd1	Protein-protein interaction
	CNOT10
	CNOT11			RNA binding
		Caf130