Table 2. Regions of Smaller Gray and White Matter Volume in 119 Adolescents With Subthreshold Depression Compared With 461 Controls.

Brain Region	Cluster Level				Voxel Level
					MNI Coordinates (mm)			p a	t
	BA	k	P		x	y	z
Gray matter
Left caudate head	–	400	.001**		−6	18	3	.001**	5.37
Right caudate head	–	234	.004**		6	20	3	.001**	5.35
Left ventromedial PFC	10	369	.002**		−12	50	6	.001**	5.24
Right anterior cingulate	24/32				3	36	0	.018*	4.63
White matter
Left forceps minor	–	69	.019*		−14	57	−2	.001**	5.09
Left ALIC	–	1288	<001***		−16	6	3	.001**	5.06
Right ALIC	–	462	.002**		12	10	−2	.006**	4.69
Right cingulum	–	191	.008**		12	32	25	.007**	4.68

Note: Empty cell indicates that region is included in the same cluster as the region immediately above. ALIC = anterior limb of internal capsule; BA = Brodmann Area; k = cluster size in number of voxels (voxel size = 3.375 mm³); MNI = Montreal Neurological Institute coordinates; PFC = prefrontal cortex.

^a Statistics at voxel level set to p < .05, familywise error corrected for the whole brain, height threshold t = 4.36 (gray matter), t = 4.16 (white matter); extent threshold k = 50 voxels.

^*p ≤.05;

^**p ≤.01;

^***p ≤.001.