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. 2022 Jul 16;140(14):1592–1606. doi: 10.1182/blood.2021014009

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© 2022 by The American Society of Hematology.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Figure 7. — MHCII high expression marks a subset of HSCs in a deeper quiescent state in human. (A) Enrichment plot of Reactome: MHC Class II Antigen Presentation from GSEA analysis of human CB LT-HSCs comparing the top 30% of CD74 expression (CD74^hi) and bottom 30% of CD74 expression (CD74^lo). (B) Selected biological pathways (c2 curated pathways; FDR < 0.05) from preranked GSEA of human CB LT-HSCs with top 30% CD74 expression (CD74^hi) compared with bottom 30% CD74 expression (CD74^lo) (50 cells) from Belluschi et al.⁵⁵ (C) Normalized expression of key MHCII regulators; FDR for differential expression between 49f+ Subset1 and 49f+ Subset2 as determined by DESeq2 shown. (D) Selected biological pathways (c2 curated pathways; FDR < 0.05) enriched in preranked GSEA analysis of 49f+Subset1 (CD34^lo/C9A^hi) and 49f+Subset2 (CD34^hi/C9A^lo) from Belluschi et al.⁵⁵ FDR, false discovery rate; NES, normalized enrichment score.