TABLE 2.

Multivariable linear mixed effects regression analysis of pulse rate and blood pressure in malaria following treatment with amodiaquine

		Pulse rate (beats/min)				Systolic blood pressure—supine (mmHg)				Diastolic blood pressure—erect (mmHg)
		Univariable analyses		Multivariable analyses		Univariable analyses		Multivariable analyses		Univariable analyses		Multivariable analyses
	Number of observations	Crude estimate (95% CI)	P value	Adjusted estimate (95% CI)	P value	Crude estimate (95% CI)	P value	Adjusted estimate (95% CI)	P value	Crude estimate (95% CI)	P value	Adjusted estimate (95% CI)	P value
Total plasma concentration of amodiaquine and desethylamodiaquine, per 750 a nmol/L increase	362	−19.51 (−23.10 to −15.92)	<.0001	−14.57 (−18.22 to −10.92)	<.0001	−18.09 (−20.99 to −15.20)	<.0001	−12.43 (−15.95 to −8.92)	<.0001	−10.64 (−13.03 to −8.25)	<.0001	−10.26 (−13.11 to −7.42)	<.0001
Body temperature change, per 1°C increase	362	9.72 (8.32–11.12)	<.0001	5.65 (3.74–7.56)	<.0001	4.46 (3.14–5.79)	<.0001			2.97 (1.94–4.00)	<.0001
Malaria	362
Yes (days 0–2)	106	−3.21 (−5.54 to −0.90)	.0066	2.98 (0.50–5.46)	.0186	−9.41 (−11.52 to −7.30)	<.0001	−4.53 (−6.93 to −2.13)	.0002	−1.13 (−2.84 to 0.58)	.1958	2.91 (0.97–4.85)	.0034
No (days 3–28)	256	Reference		Reference		Reference		Reference		Reference		Reference
Sex	362
Female	193	Reference		Reference		Reference				Reference
Male	169	3.06 (−4.81 to 10.93)	.4388	4.12 (−4.17 to 12.41)	.3232	2.52 (−3.74 to 8.78)	.4231			4.14 (−0.80 to 9.08)	.0985

^a Mean maximum total plasma drug concentration (rounded) after a 3‐day course of amodiaquine from pharmacokinetic analysis of same study.

CI, confidence interval.