. 2022 Nov 8;89(3):1176–1186. doi: 10.1111/bcp.15569

TABLE 3.

Multivariable linear mixed effects regression analysis of the corrected QT interval in malaria following treatment with amodiaquine

		QTcS—Study‐specific correction (ms)				QTcF—Fridericia correction (ms)				QTcB—Bazett correction (ms)
		Univariable analyses		Multivariable analyses		Univariable analyses		Multivariable analyses		Univariable analyses		Multivariable analyses
	Number of observations	Crude estimate (95% CI)	P value	Adjusted estimate (95% CI)	P value	Crude estimate (95% CI)	P value	Adjusted estimate (95% CI)	P value	Crude estimate (95% CI)	P value	Adjusted estimate (95% CI)	P value
Total plasma concentration of amodiaquine and desethylamodiaquine, per 750 ^a nmol/L increase	356	12.98 (8.73–17.16)	<.0001	10.43 (5.92–15.00)	<.0001	20.35 (15.56–25.15)	<.0001	10.67 (6.13–15.21)	<.0001	6.10 (1.80–10.38)	.0055	10.26 (5.71–14.81)	<.0001
Body temperature change, per 1°C increase	356	−5.30 (−7.12 to −3.47)	<.0001	−3.97 (−6.49 to −1.46)	.0021	−10.59 (−12.52 to −8.65)	<.0001	−4.04 (−6.57 to −1.52)	.0018	−0.374 (−2.25 to 1.50)	.6948	−3.90 (−6.43 to −1.37)	.0026
Sex	356
Female	187	Reference		Reference		Reference		Reference		Reference		Reference
Male	169	−16.24 (−25.48 to −7.00)	.0009	−17.35 (−26.62 to −8.08)	.0004	−12.72 (−22.11 to −3.34)	.0088	−13.30 (−22.94 to −3.66)	.0078	−19.54 (−29.00 to −10.08)	.0001	−21.05 (−30.57 to −11.52)	<.0001
Age, per 10‐year increase	356	2.33 (−0.25 to 0.71)	.3339	4.16 (−0.17 to 8.49)	.0595	2.87 (−1.78 to 7.52)	.2209	4.47 (−0.30 to 8.98)	.0515	1.78 (−3.32 to 6.88)	.4859	3.87 (−0.57 to 8.32)	.0864
RR interval change, per 300 ^b ms increase	356	7.50 (4.46–10.54)	<.0001	−0.42 (−4.80 to 3.95)	.8475	19.69 (16.65–22.74)	<.0001	11.63 (7.25–16.01)	<.0001	−3.69 (−6.75 to −0.65)	.0177	−11.45 (−15.84 to −7.06)	<.0001

$QTcS = \frac{QT}{{RR}^{0.42}} & QTcF = \frac{QT}{\sqrt[3]{RR}} & QTcB = \frac{QT}{\sqrt{RR}},$ where RR is in units of s.

^{^a}

Mean maximum total plasma drug concentration (rounded) after a 3‐day course of amodiaquine from pharmacokinetic analysis of same study.

^{^b}

Mean change in RR interval from baseline (rounded) after last dose of amodiaquine treatment in this study.

CI, confidence interval.