Illustrative examples of sampled lung areas with ex vivo CT, micro-CT,
and histologic staining. (A) Axial noncontrast ex vivo CT
scan shows highly abnormal (25% healthy, 55% reticulation, 20%
ground-glass opacification) lung findings. (B–E)
Micro-CT scan (B) and histopathologic images
(hematoxylin-eosin [C, D] and trichrome [E]
staining; magnification, ×5 for C and
E, ×20 for D) of the area highlighted
with the circle in A show paraseptal and interstitial
fibrotic changes. (F) Axial noncontrast ex vivo CT scan
shows lung considered healthy (80%), with mild ground-glass
opacification (15%) and limited reticulation (5%).
(G–J) Micro-CT scan (G) and
histopathologic images (hematoxylin-eosin [H, I] and
trichrome [J] staining; magnification, ×5 for
H and J, ×20 for I) of
the matched location (circle in F) show paraseptal and
interstitial fibrosis. Awy = airway, BV = blood vessel.