Figure 21. Haemoglobin trends between Duke’s A and D tumour stage by age at index date ^1,2.

¹Index date was the date of diagnosis for cases and a randomly selected date in the patient’s study period for controls. ²LOWESS trends are age (+/- 3 years) and modelled (fixed effects) trends are taken at that specific age. Legend: males (left) and females (right). Stage A (blue line) and Stage D (red line). LOWESS trend (solid line) and modelled trend (dashed line).