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. Author manuscript; available in PMC: 2023 May 3.
Published in final edited form as: Sci Immunol. 2022 Mar 11;7(69):eabm0775. doi: 10.1126/sciimmunol.abm0775

Figure 1. Identification of light zone cells initiating cyclic re-entry in Fucci2 mice.

Figure 1

Analysis of splenic responses in Fucci2 mice on day 8 post-SRBC immunisation. (A) GC B cell DZ and LZ populations identified as shown. (B) G1 cells and S-G2-M phase cells are identified. mCherry levels accumulate with time post-mitosis, and mVenus accumulates with time in S phase; as such, early S phase cells are mCherryhigh mVenuslow. (C) LZ cells are mostly resting and therefore have higher mCherry levels than DZ cells. Dashed line provided to aid comparison. LZ cells initiating cyclic re-entry (early S phase) are identified by the red box.