Skip to main content
. Author manuscript; available in PMC: 2023 May 13.
Published in final edited form as: Cell. 2023 May;186(10):2238–2255.e20. doi: 10.1016/j.cell.2023.04.018

Figure 3. Sequence of events in β2AR-βArr2 interactions.

Figure 3

(A) Simplified representation of the results of the Markov chain analysis. Dashed circles, corresponding basal occupancies. See Table S3 for full transition probabilities.

(B) Changes in single-molecule state occupancies induced by isoproterenol (10 μM) stimulation. Data are normalized to the corresponding basal levels.

(C) Example of a βArr2 molecule undergoing a transient interaction with a β2AR to then reach a CCP without an accompanying receptor.

(D) Examples of βArr2 molecules visiting multiple CCPs via lateral diffusion.

See also Figures S3 and S4 and Table S5.