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. Author manuscript; available in PMC: 2023 May 22.
Published in final edited form as: J Rheum Dis Treat. 2016 Jun 30;2(2):1510033. doi: 10.23937/2469-5726/1510033

Figure 1. Novel application of combined behavioral measures to assess motor function and locomotor activity in experimental arthritis.

Figure 1

(A) Schematic representation of longitudinal behavioral assessment during AIA. Blue arrows denote habituation to the behavioral tasks, 4 sessions of baseline measurement, and 7 testing days; (B) Significantly greater knee swelling in AIA-injected mice compared to PBS-injected mice; (C) No significant effect of PBS or AIA injection on stride length; (D) Latency to turn is not significantly different between the groups; (E) AIA-treated mice transiently demonstrate significantly longer latency to traverse the balance beam than PBS-treated mice; (F&G) AIA injection induced a significant transient increase in the number of foot slips made by both hind limbs; (H) Open field testing revealed a transient reduction in total distance moved and (I) time spent moving in the AIA-treated group compared to the PBS-treated group. Tracks show representative movement (black line) on day 2 post injection, when the AIA-injected group are significantly less active that the PBS-injected group.

B–baseline testing day; Graphs represent mean ± SEM; Significant effect of Group: *p ≤ 0.05; Significant Group*Day interaction: $$p ≤ 0.01, $$$p ≤ 0.001.