Table 5. MR-Egger pleiotropy test of associations between a 25 nmol/L increase in genetically determined season-standardized 25(OH)D and risk of lung cancer overall and histologic types in the HUNT2 study (n=54580).
| Outcome | MR-Egger method | ||
|---|---|---|---|
| Intercept (95% CI) | P value | ||
| Lung cancer overall | -0.03 | (-0.25 to 0.72) | 0.79 |
| SCLC | -0.27 | (-1.27 to 0.72) | 0.59 |
| Adenocarcinoma | -0.14 | (-0.55 to 0.27) | 0.50 |
| Squamous cell carcinoma | 0.36 | (-0.12 to 0.84) | 0.14 |
| Other/unknown subtypes | -0.09 | (-0.45 to 0.28) | 0.64 |
25(OH)D: 25-hydroxyvitamin D; CI: confidence interval; MR: Mendelian randomization; SCLC: small cell lung cancer