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. 2023 Mar 31;325(1):H1–H29. doi: 10.1152/ajpheart.00705.2022

Table 2.

Main characteristics of existing 1-D models

References Closed-Loop Heart Model Systemic Circulation Pulmonary Circulation Coronary Circulation Cerebral Circulation Tube Law Velocity Profile Convective Acceleration Distal Vasculature Models
Streeter et al. (42) − (aorta) NLE − P R
Schaaf and Abbrecht (43) + LE − P R
Wemple and Mockros (44) + NLE + W + 3Wk
Raines et al. (45) − (leg) NLE − P 3Wk
Avolio (46) + + VE + W R
Stettler et al. (47, 48) + + NLE − P R
Kufahl and Clark (49) − (cerebral) + NLE − p + 3Wk
Hillen et al. (50) − (cerebral) + LE − P R
Papapanayotou et al. (51) − (cerebral) + LE − P R
Fitchett (52) +1 C + + VE + W R
Stergiopulos et al. (29) + NLE − P + 3Wk
Cassot and Zagzoule (53) − (cerebral) + LE − P R
Olufsen (33) + LE + BL ST
Wan et al. (54) + LE − P + R
Sherwin et al. (55) + LE − F R
Wang and Parker (56) + LE − F R
Formaggia et al. (30) +1 C + LE − P 3Wk
Azer and Peskin (34) + LE + W + ST
Bessems et al. (57) − (aorta and coronary) LE + BL + 3Wk
Huo and Kassab (35) − (coronary) + LE − P + ST
Liang et al. (38) + +4 C + + LE − p Wk+
Reymond et al. (21) +1 C + + + VE + W + 3Wk
Blanco et al. (26) + + + VE1 − P 3Wk
Müller and Toro (31) + +4 C + + LE − P Wk+
Qureshi et al. (27) + LE + BL ST
Mynard and Smolich (39) + +4 C + + + + VE3 − p Wk+2
Acosta et al. (58) + +4 C + + LE − p Wk+2
Carson et al. (59) + +4 C + + + VE + BL 3Wk+
Charlton et al. (28) + + VE − p 3Wk
Gallo et al. (41) + +4 C + + VE + BL 3Wk+
Westerhof et al. (60) + + VE − P 3Wk

Closed-loop: a closed-loop model of the circulation is (+) or not (−) included. Heart model: a heart model is (+) or not (−) coupled to the one-dimensional (1-D) model vessels, with the number of heart chambers (C) indicated. Systemic circulation: the larger systemic arteries are simulated using 1-D modeling (+), as opposed to none or a few arteries as indicated (−). Pulmonary circulation: the larger pulmonary arteries are simulated using 1-D modeling (+), as opposed to none or a few arteries (−). Coronary circulation: the larger coronary arteries are simulated using 1-D modeling (+), as opposed to none or a few arteries (−). Cerebral circulation: the larger cerebral arteries, including the circle of Willis, are simulated using 1-D modeling (+), as opposed to none or a few arteries (−). Tube law: Arterial wall modeled as a linear (LE) or nonlinear (NLE) purely elastic material, or as a viscoelastic (VE) material. Velocity profile: profile calculated (+) using Womersley flow (W) or a boundary layer method (BL), or prescribed (−) using Poiseuille flow (P), a higher-order polynomial (p), a boundary layer method (BL), or a flat profile (F). Convective acceleration: Full term simulated (+) or either simplified by assuming a flat velocity profile or completely neglected (−). Distal vasculature models: single resistance (R), three-element Windkessel (3Wk), Windkessel with more than three elements (Wk+), structured-tree (ST).

1

Elastin, collagen, smooth muscle contributions accounted for; 2Nonlinear 0-D models, with specific models for the hepatic and coronary beds; 3Nonlinear elastic term using a power law and Voigt-type viscous term.