. Author manuscript; available in PMC: 2023 Jun 5.

Published in final edited form as: Int J Epidemiol. 2019 Oct 1;48(5):1727–1730. doi: 10.1093/ije/dyz047

Table 1. Associations between individual SNPs in the HMGCR region and LDLC, BMI, and breast cancer.^a.

SNP	Allele	LDLC		BMI		ER-pos BC		ER-neg BC		Overall BC		ER-pos/ER-neg
SNP	Allele	Beta	P	Beta	P	Beta	P	Beta	P	Beta	P	HetP
rs10066707	G	-0.0497	3.0E-19	0.0097	0.02	-0.0112	0.15	-0.0113	0.34	-0.0136	0.04	0.99
rs12916	T	-0.0733	7.8E-78	0.0182	7.3E-09	-0.0136	0.07	-0.0105	0.36	-0.0113	0.07	0.82
rs17238484	G	-0.0627	1.4E-21	--	--	-0.0237	0.01	-0.0151	0.26	-0.0156	0.03	0.59
rs2006760	C	-0.0533	1.7E-13	0.006	0.27	-0.0161	0.08	-0.0052	0.71	-0.0135	0.08	0.52
rs2303152	G	-0.0423	1.0E-09	0.0158	2.8E-03	-0.0222	0.07	-0.0005	0.98	-0.0077	0.45	0.33
rs5909	G	-0.0617	4.9E-13	-0.0008	0.90	0.0066	0.59	0.0057	0.76	-0.0029	0.78	0.97
rs2112347^b	T	-0.0443	4.4E-30	0.0261	6.2E-17	-0.0154	0.04	-0.0343	3.3E-03	-0.0183	4.4E-03	0.18

Obtained from the data sets in references 3,10, and 11.

rs2112347 is the SNP most strongly associated with BMI in the HMGCR region in the BMI genetic association meta-analysis.³

Beta coefficients are signed with reference to the allele shown.

Abbreviations: BC: breast cancer; ER-pos: estrogen receptor positive; ER-neg: estrogen receptor negative; LDLC: low density lipoprotein cholesterol; BMI: body mass index, Het P: P-value from Cochran's Q test for heterogeneity.

Table 1. Associations between individual SNPs in the HMGCR region and LDLC, BMI, and breast cancer.a.

Table 1. Associations between individual SNPs in the HMGCR region and LDLC, BMI, and breast cancer.^a.