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. Author manuscript; available in PMC: 2023 Jun 6.
Published in final edited form as: Clin Cancer Res. 2020 Oct 7;27(1):288–300. doi: 10.1158/1078-0432.CCR-20-3237

Figure 3. Inflammatory and immune response-related pathways are elevated in DDIR positive tumours.

Figure 3

A) Gene set enrichment analysis on the two CRC cohorts (FOCUS and FOxTROT) and a BC cohort (TRANSBIG) identifies five common pathways associated with DDIR positive tumours in both cancer types; Benjamini-Hochberg False Discovery Rate (FDR) < 0.25 considered significant, Normalised Enrichment Score (NES) bar (DDIR POS > 0, DDIR NEG < 0). B) Expression of CXCL10 correlated with DDIR scores in TRANSBIG, C) FOCUS, and D) FOxTROT cohort, displayed with line of best fit (blue).