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. Author manuscript; available in PMC: 2023 Jun 14.
Published in final edited form as: Nat Med. 2022 Nov 10;28(11):2293–2300. doi: 10.1038/s41591-022-02055-z

Figure 4. Characterization of the association between top impaired glucose tolerance and isolated impaired glucose tolerance discriminatory proteins and glycaemic traits, future T2D risk and genetic predisposition to metabolic phenotypes.

Figure 4

a,Association of top IGT and iIGT discriminatory proteins with fasting and 2-hour glucose and insulin in the Fenland study (N = 10259 individuals). Beta estimates with 95% CIs are shown. b, Association of top IGT and iIGT discriminatory proteins with incident T2D in the WHII study (N = 1492, 521 incident T2D cases). Hazard ratios (HR) with 95% CIs are shown. c, Association of GRSs for FG, FI, 2hPG, T2D and BMI with top IGT and iIGT discriminatory proteins in the Fenland study (N = 7973 individuals). Beta estimates with a 95% CIs are shown.