Table 1. Baseline characteristics of cohort.
| No RRSO n = 337, 49.3% | RRSO n = 346, 50.7% | P-value | |
|---|---|---|---|
| Mean age in years (SD, range) | 38.25 (10.23, 19-81) | 51.53 (9.56, 26-81) | <0.001 |
| Mean parity (SD, range) | 1.92 (0.83, 1-6) | 2.18 (0.86, 1-7) | <0.001 |
| Nulliparous | 217/336, 64.6 | 286/343, 83.4 | <0.001 |
| Premenopausal/premenopausal at time of RRSO | 262/335, 78.2 | 164/248, 66.1 | 0.001 |
| Postmenopausal/postmenopausal at time of RRSO | 73/335, 21.8 | 84/248, 33.9 | 0.001 |
| Family complete | 194/331, 58.6 | 318/334, 95.2 | <0.001 |
| High risk of OC | |||
| BRCA1 carrier | 157/337, 46.6 | 162/346, 46.8 | 1 |
| BRCA2-carrier | 171/337, 50.7 | 161/346, 46.5 | 0.284 |
| BRCA1- and BRCA2-carrier | 5/337, 1.5 | 7/346, 2.0 | 0.773 |
| Intermediate risk of OC | |||
| RAD51C-carrier | 0/337, 0.0 | 1/346, 0.3 | |
| BRIP1-carrier | 3/337, 0.9 | 1/346, 0.3 | 0.367 |
| BRCA1/BRCA2-negative but strong FH of OC | 1/337, 0.3 | 2/346, 0.6 | 1 |
| BRCA1/BRCA2 untested but strong FH of OC | 1/337, 0.3 | 3/346, 0.9 | 0.624 |
| Unsure of genetic test result | 4/337, 1.2 | 6/346, 1.7 | 0.752 |
| Personal history of BC | 77/337, 22.8 | 160/346, 46.2 | <0.001 |
| Personal history of other cancers | 6/337, 1.8 | 9/346, 2.6 | 0.604 |
| Therapeutic mastectomy | 20/337, 5.9 | 47/346, 13.6 | 0.001 |
| Risk-reducing mastectomy | 70/337, 20.8 | 143/346, 41.3 | <0.001 |
| Breast surgery for benign breast pathology | 0/337, 0.0 | 4/346, 1.2 | |
| Cosmetic breast surgery | 2/337, 0.6 | 1/346, 0.3 | 0.620 |
| Marital status | |||
| Single, divorced, separated, widowed | 72/332, 21.7 | 36/341, 10.6 | <0.001 |
| Married, cohabiting/living with partner | 260/332, 78.3 | 305/341, 89.4 | <0.001 |
| Ethnicity | |||
| Caucasian | 301/334, 90.1 | 300/341, 88.0 | 0.391 |
| Non-caucasian | 33/334, 9.9 | 41/341, 12.0 | 0.391 |
| Education | |||
| PhD, Masters, Bachelor’s degree | 199/329, 60.5 | 141/336, 42.0 | <0.001 |
| NVQ4, A-level/NVQ3, NVQ1/NVQ2, GCSE/O-level/CSE, no formal qualification | 130/329, 39.5 | 195/336, 58.0 | <0.001 |
| Total household income | |||
| ≥£30 000 | 236/325, 72.6 | 208/312, 66.7 | 0.121 |
| <£30 000 | 89/325, 27.4 | 104/312, 33.3 | 0.121 |
BC, breast cancer; FH, family history; OC, ovarian cancer; RRSO, risk-reducing salpingo-oophorectomy.
90/773 participants were excluded because they were at population-level risk of ovarian cancer. 683 participants eligible for analysis.