Table 4. Factors associated with retrospective acceptability of RRESDO among women who have undergone premenopausal RRSO.
| OR | SE | P >|z| | 95% CI | |
|---|---|---|---|---|
| Prior knowledge of tubal origin of ovarian cancer | 1.514 | 0.444 | 0.35 | 0.63-3.625 |
| Personal history of breast cancer | 0.731 | 0.468 | 0.504 | 0.289-1.824 |
| Previous risk reducing mastectomy | 0.618 | 0.456 | 0.291 | 0.249-1.5 |
| Carrier status | 1.626 | 0.898 | 0.589 | 0.31-12.385 |
| Marital status | 0.716 | 0.458 | 0.466 | 0.291-1.768 |
| Ethnicity | 1.184 | 0.635 | 0.791 | 0.321-4.058 |
| Education | 1.11 | 0.398 | 0.793 | 0.507-2.433 |
| Income | 1.079 | 0.194 | 0.695 | 0.739-1.589 |
| FH | ||||
| BC | 1.445 | 0.896 | 0.682 | 0.281-11.041 |
| OC | 1.754 | 1.120 | 0.616 | 0.198-18.561 |
| BC and OC | 0.944 | 1.166 | 0.961 | 0.083-9.194 |
| Experienced menopausal sequelae following RRSO | ||||
| Hot flushes | 0.09 | 0.955 | 0.013 | 0.013-0.566 |
| Night sweats | 13.76 | 1.108 | 0.018 | 1.729-140.177 |
| Sleep disturbance | 18.78 | 0.988 | 0.003 | 3.186-160.144 |
| Vaginal dryness | 0.76 | 0.658 | 0.671 | 0.204-2.774 |
| Sexual dysfunction | 5.34 | 0.779 | 0.031 | 1.244-27.467 |
| Loss of fertility | 0.70 | 0.669 | 0.587 | 0.174-2.501 |
| Osteoporosis | 0.25 | 0.700 | 0.045 | 0.057-0.919 |
| Urinary incontinence | 17.20 | 0.807 | <0.001 | 3.985-98.597 |
| Fatigue | 0.01 | 1.150 | <0.001 | 0.001-0.096 |
| Memory loss | 0.67 | 0.662 | 0.541 | 0.177-2.45 |
| Mood alterations | 3.06 | 0.684 | 0.102 | 0.834-12.654 |
| Impact on relationship with partner | 1.81 | 0.676 | 0.379 | 0.49-7.158 |
| Satisfaction/regret following RRSO | ||||
| I regret the choice that was made | 6.385 | 0.866 | 0.032 | 1.251-40.746 |
| I would make the same decision if I had to do it over again | 0.471 | 4.597 | 0.87 | 0.001-205.952 |
| The decision did me a lot of harm | 3.877 | 0.590 | 0.022 | 1.226-12.795 |
| I was directly influenced by the direct wishes of my family | 3.762 | 0.700 | 0.058 | 0.974-15.615 |
| I was influenced by the unexpressed wishes of my family | 0.401 | 0.734 | 0.212 | 0.089-1.631 |
BC, breast cancer; FH, family history; HRT, hormone replacement therapy; OC, ovarian cancer; RRESDO, risk-reducing early salpingectomy with delayed oophorectomy; RRM, risk-reducing mastectomy.
Multiple logistic regression analysis on factors affecting retrospective acceptability (‘probably, maybe’ versus ‘probably not, definitely not’ responses) of undergoing RRESDO had it been an option in 159 women who have undergone premenopausal RRSO. Model adjusted for marital status, ethnicity, education, income, family history of ovarian cancer/breast cancer, risk-reducing mastectomy and personal history of breast cancer. Prior knowledge of tubal origin of OC: ‘yes’ versus ‘no’; personal history of BC: ‘yes’ versus ‘no’; previous RRM: ‘yes’ versus ‘no’; family complete: no versus yes; carrier status: BRCA1/BRCA2 versus intermediate risk (RAD51C carrier/RAD51D carrier/BRIP1 carrier/BRCA-negative but strong FH of OC/BRCA untested but strong FH of OC); marital status: in a relationship (married, cohabiting/living with partner) versus not in a relationship (single, divorced, separated, widowed); ethnicity: non-caucasian versus caucasian; education: university level education (PhD, Masters, Bachelor’s degree) versus below university level education (NVQ4, A-level/NVQ3, NVQ1/NVQ2, GCSE/O-level/CSE, no formal qualification); timing of future OC prevention surgery: planning surgery now/within 5 years versus not planning surgery; FH BC (FH of BC alone plus FH of BC and OC): ‘yes’ versus ‘no’; FH OC (FH of OC alone plus FH of OC and BC): ‘yes’ versus ‘no’; FH BC and OC: ‘yes’ versus ‘no’; hot flushes: ‘yes’ versus ‘no’; night sweats: ‘yes’ versus ‘no’; sleep disturbance: ‘yes’ versus ‘no’; vaginal dryness: ‘yes’ versus ‘no’; sexual dysfunction: ‘yes’ versus ‘no’; loss of fertility: ‘yes’ versus ‘no’; osteoporosis (self-reported): ‘yes’ versus ‘no’; urinary incontinence: ‘yes’ versus ‘no’; fatigue: ‘yes’ versus ‘no’; memory loss: ‘yes’ versus ‘no’; mood alterations: ‘yes’ versus ‘no’; impact of relationship with partner: ‘yes’ versus ‘no’; it was the right decision: ‘yes’ versus ‘no’; I regret the choice that was made: ‘yes’ versus ‘no’; I would make the same decision if I had to do it over again: ‘yes’ versus ‘no’; the decision did me a lot of harm: ‘yes’ versus ‘no’; the decision was a wise one: ‘yes’ versus ‘no’; I was directly influenced by the direct wishes of my family: ‘yes’ versus ‘no’; I was influenced by the unexpressed wishes of my family: ‘yes’ versus ‘no’.