Table 1. Steady state kinetic parameters for faropenem turnover including reported values.
| Enzyme | Type | Class | kcat (s-1) | KM (μM) | kcat/KM (s-1 μM-1) | Ki (μM) |
|---|---|---|---|---|---|---|
| KPC-2 | SBL | A | 3.71 (0.21) | 16.6 (3.84) | 0.22 | 44.1 (25.0) |
| VIM-2 | MBL | B1 | 36.7 (1.03) | 5.11 (0.63) | 7.17 | - |
| L1 | MBL | B3 | 43.7 (2.70) | 36.3 (8.80) | 1.20 | - |
| BlaC[24] | SBL | A | 0.91 (0.03) | 23 (3) | 0.040 | - |
| NDM-1[31] | MBL | B1 | 14.7 (0.08) | 99 (0.16) | 0.15 | - |
| BJP-1[32] | MBL | B3 | 2 (<0.2) | 245 (<25) | 0.008 | - |
Standard errors of the mean in parenthesis (n=3). See Experimental Section for KPC-2, VIM-2 and L1 assay details.