Table 3. APCCC 2022 questions concerning importance of lifestyle and prevention of side effects caused by hormonal therapy that have reached consensus.

Question	Answers	Voting results, % (n)
125. Do you recommend checking drug-drug interaction (yourself or by a pharmacist) in patients with mHSPC before the start of an AR pathway inhibitor (Abi/Apa/Daro/Enza) in addition to ADT?	1. Yes	95 (93), strong consensus
	2. No	5(5)
126. Do you recommend checking for drug-drug interactions (yourself or by a pharmacist) if other drugs are commenced after a patient has started an AR pathway inhibitor?	1. Yes	91 (90), strong consensus
	2. No	9(9)
129. In the majority of patients with mHSPC for whom you recommend initiating denosumab or a bisphosphonate, which dose and schedule do you use?	1. Denosumab (q6 mo) or bisphosphonates (oral or q12 mo)	75 (72), consensus
	2. Denosumab 120 mg q4 wk or zoledronic acid q3–4 wk	5(5)
	3. I do not recommend these drugs in mHSPC	20 (19)
132. In the majority of patients with mHSPC for whom you recommend an osteoclast-targeted therapy, do you recommend a dental check before initiation of treatment?	1. Yes	92 (89), strong consensus
	2. No	8(8)

Abi = abiraterone; ADT = androgen deprivation therapy; Apa = apalutamide; APCCC = Advanced Prostate Cancer Consensus Conference; AR = androgen receptor; Daro = darolutamide; Enza = enzalutamide; mHSPC = metastatic hormone-sensitive prostate cancer.