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. Author manuscript; available in PMC: 2023 Jul 12.
Published in final edited form as: Mol Psychiatry. 2022 Nov 16;28(3):1128–1136. doi: 10.1038/s41380-022-01871-6

Table 2. DNA methylation at birth and general psychopathology: meta-analytic associations with p < 1 × 10−5.

CpG Gene Chr Position n B SE p Direction I2 Heterogeneity p-value
cg02084087 TNFRSF25 chr1 6526049 2175 4.31 0.95 5.54 × 10−6 ++++ 46.2 0.13
cg11777523 GPR148 chr2 131485418 2019 9.26 2.07 7.80 × 10−6 +?++ 23.6 0.27
cg14358879 SLC8A3 chr14 70655920 2174 -7.82 1.75 8.20 × 10−6 ---- 33.7 0.21
cg09437808 - chr5 176107069 2177 2.46 0.55 8.96 × 10−6 ++++ 0 0.47

Chr chromosome, n number of participants, SE standard error, Direction direction of the effect per study (ALSPAC, DCHS, GENR, INMA) in alphabetical order (+ = positive direction, − = negative direction, ? = not present); I2 heterogeneity statistic reflecting the variation attributable to heterogeneity across studies (high values suggest high heterogeneity)

Effect estimates (B) represent the SD increase in GPF for each increase of 100% in DNAm.