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. Author manuscript; available in PMC: 2023 Jul 14.
Published in final edited form as: Nat Genet. 2023 Jun 8;55(6):973–983. doi: 10.1038/s41588-023-01408-9

Figure 1. Loci associated with post-challenge insulin resistance overlap with associations with other glycaemic traits and T2D.

Figure 1

Manhattan plot of results for IFC, ISI and relative association with key glycaemic traits of interest. Y-axis denotes the -log10(p-value) of association for each trait. X-axis outlines the chromosomal position, with alternate chromosomes represented in light and dark grey. The dashed line defines genome-wide significance threshold (P = 5x10-8), and the dotted line denotes P = 1x10-5. Points highlighted in blue on each plot represent those that meet genome-wide significance for either IFC and ISI (P < 5x10-8). Labels for indicate the nearest gene at a locus defined at genome-wide significance for either IFC and ISI, and their relative association with other traits. Published GWAS were used for fasting insulin and 2 h glucose3,, and T2D26. For T2D y axis is cut at 1x10-80 for clarity, with the minimum p value truncated to P = 1x10-300. Uncorrected p-values are shown. All GWAS are in cohorts of European ancestry and adjusted for BMI, except T2D which is unadjusted for BMI.