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. Author manuscript; available in PMC: 2023 Jul 14.
Published in final edited form as: Nat Genet. 2023 Jun 8;55(6):973–983. doi: 10.1038/s41588-023-01408-9

Extended Data Figure 3. Observational Correlation of insulin sensitivity and clearance related traits in the RISC study.

Extended Data Figure 3

Pairwise Spearman’s Rank correlation. Red shades denote positive correlation, blue shared denote negative correlation between trait pairs, legend along bottom of heatmap shows colour scale relative to rho value. X denotes no significant correlation (P > 0.05). Abbreviations denote: IFC_OGTT – IFC calculated using OGTT measures, ISI_OGTT – Modified Stumvoll ISI calculated using OGTT measures. M_I – M/I index of insulin sensitivity measured by clamp. InsC0c – insulin measured at 0min during clamp. InsO0c - insulin measured at 0min during OGTT. InsC120c – insulin measured at 120min during clamp. InsO120c - insulin measured at 120min during OGTT. InsC_20c – insulin measured at 20min before clamp. EGP_B -basal glucose production, EGP_SS - glucose production during clamp, GCR_B - basal glucose clearance, ml/min/kg lean body mass, GCR_SS - steady state glucose clearance, ml/min/kg lean body mass, icl_clamp - peripheral insulin clearance (1/min/m2), icl_OGTT - endogenous "pre-hepatic" clearance during the OGTT, hie_0 - hepatic insulin extraction during clamp, OGIS - oral glucose insulin sensitivity index (ml min-1 m-2). ISR5dr - insulin secretion 5 mM glucose, beta cell dose response (pmol min-1m-2). ISR0 basal insulin secretion (pmol min-1m-2). ISRtot - total insulin secretion (nmol m-2).