. Author manuscript; available in PMC: 2023 Jul 14.

Published in final edited form as: Nat Genet. 2023 Jun 8;55(6):973–983. doi: 10.1038/s41588-023-01408-9

Table 1. Genome wide significant loci for Insulin fold change and Modified Stumvoll ISI, adjusted for BMI in meta-analysis of cohorts of European ancestry.

Trait	Locus	CHR:POS	rsid	EA	OA	EAF	Beta	SE	P-value	N
Insulin Fold Change	MTN1RB	11:92673828	rs1387153	T	C	0.3023	0.0438	0.0069	2.25E-10	52698
	PPP1R3B (primary)	8:9173358	rs7012814	A	G	0.4796	0.0481	0.0065	1.35E-13	52458
	PPP1R3B (secondary)	8:9185146	rs2126259	T	C	0.1265	-0.0688	0.0099	2.86E-12	52698
	C2CD4A	15:62396189	rs7167878	A	C	0.4606	-0.0426	0.0064	2.76E-11	53287
	SLC2A4	17:7185779	rs11764318 0	A	C	0.0231	0.1428	0.0221	1.11E-10	50671
Modified Stumvoll ISI	IRS1	2:227101411	rs2972144	A	G	0.366	0.0644	0.0067	1.10E-21	50511
	COBLL1	2:165558252	rs12692738	T	C	0.7724	-0.0568	0.0075	5.24E-14	53657
	PPARG	3:12385828	rs11128603	A	G	0.8595	-0.0635	0.0091	2.64E-12	53657
	SLC2A4	17:7185779	rs11764318 0	A	C	0.0231	-0.1416	0.0221	1.58E-10	51187
	C5orf67	5:55806751	rs459193	A	G	0.2816	0.0409	0.007	6.18E-09	53657
	MTOR	1:11322628	rs2295080	T	G	0.6961	-0.0394	0.0069	1.34E-08	53657
	BCL2	18:60845884	rs12454712	T	C	0.5858	-0.0374	0.0068	4.42E-08	52701
	FAM101A	12:124539537	rs1906937	A	C	0.2894	-0.0384	0.007	4.86E-08	53657

EA – effect allele, OA – other allele, EAF – effect allele frequency, SE – standard error. CHR:POS – chromosome:position GRCh37 (hg19).