A sample size program by Abdel Babiker, Patrick Royston, Friederike Barthel, Ella Marley-Zagar and Ian White MRC Clinical Trials Unit at UCL, London WC1V 6LJ, UK.
Type of trial	superiority
Number of groups	4
Favourable/unfavourable outcome	not determined
Allocation ratio	equal group sizes
Statistical test assumed	unconditional comparison of 4 binomial proportions using the score test
Local or distant	distant
Continuity correction	no
Anticipated event probabilities	0.100 0.200 0.300 0.400
Alpha	0.100 (two-sided)
Power (designed)	0.900
Total sample size (calculated)	176
Sample size per group (calculated)	44 44 44 44
Expected total number of events	44.00