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. Author manuscript; available in PMC: 2023 Jul 21.
Published in final edited form as: Cell Microbiol. 2019 Nov 17;22(2):e13140. doi: 10.1111/cmi.13140

Figure 6.

Figure 6

Model depicting Ifu5 functions in Candida albicans. Ifu5 influences normoxic and hypoxic responses in C. albicans. Ifu5 represses PMT1 expression via the Cek1 MAP kinase pathway to maintain glycosylation homeostasis and thus cell wall integrity under normoxia. Direct binding of Ifu5 to Efg1 (grey blunt arrow) represses the function of this regulator. Hypoxia relieves this repression, and a negative reciprocal loop (grey blunt arrows) of regulation between IFU5 and EFG1 allows rapid hypoxic adaptation. Ifu5 positively regulates hypoxic biofilm formation and hyphal morphogenesis in both normoxic and hypoxic conditions