Table 1. Functional category of C. albicans genes whose transcript levels in the ifu5Δ/Δ strain are 1.5-fold up- and down-regulated (P≤ 0.05).
| Category and System Name | Gene | Function | Fold Change |
|---|---|---|---|
| Protein modification degradation and transport | |||
| orf19.1557 | RKM5 | S-adenosylmethionine-dependent methyltransferase activity | -7.34 |
| orf19.1805 | PEX14 | role in protein import into peroxisome matrix | 3.73 |
| orf19.5612 | BMT4 a,b,c | Beta-mannosyltransferase | 3.24 |
| orf19.5440 | RPT2 b | Putative ATPase of the 19S regulatory particle of the 26S proteasome | 1.96 |
| orf19.7106 | VPS70 | Ortholog(s) have role in protein targeting to vacuole | 1.76 |
| Cell Surface | |||
| orf19.3638 | PGA46 | GPI-anchored cell wall protein involved in cell wall synthesis | -2.62 |
| orf19.6420 | PGA13 b | GPI-anchored cell wall protein involved in cell wall synthesis | -1.88 |
| orf19.848 | PGA16 b | Putative GPI-anchored protein | -1.86 |
| orf19.6302 | PGA39 | GPI-anchored protein | 1.85 |
| orf19.3738 | PGA22 | Putative GPI-anchored protein | 1.54 |
| orf19.4555 | ALS4 b | GPI-anchored adhesion, Role in adhesion | 1.64 |
| orf19.1816 | ALS3 b,c | Cell wall adhesion, Promotes biofilm formation | 1.63 |
| Hypha formation and Virulence | |||
| orf19.5454 | FGR12 b | Filamentous growth | -5.17 |
| orf19.6339 | NRG2 | Transcription factor involved in biofilm | -3.60 |
| orf19.4067 | FGR18 | Filamentous growth | -2.61 |
| orf19.935 | AGA1 b | Spider biofilm induced | -2.47 |
| orf19.610 | EFG1 a,b | Transcription factor involved in biofilm | 2.73 |
| orf19.822 | HSP21 b | Small heat shock protein | -3.01 |
| Iron assimilation | |||
| orf19.1673 | PPT1 | Induced in high iron | -2.24 |
| orf19.6140 | FRE30 c | Protein with similarity to ferric reductases | 3.19 |
| Mitochondrial Function and Oxidation-Reduction Processes | |||
| CaalfMp01 | COX2 a | Subunit II of cytochrome c oxidase | -2.05 |
| orf19.6100 | CRD1 b | Cardiolipin synthase | -1.70 |
| orf19.6662 | COQ10 | Putative coenzyme Q (ubiquinone) binding protein | -1.50 |
| CaalfMp03 | NAD1 c | Subunit 6 of NADH:ubiquinone oxidoreductase (NADH:ubiquinone dehydrogenase) | -2.59 |
| orf19.7111.1 | SOD3 a,b,c | Cytosolic manganese-containing superoxide dismutase | 2.9 |
a
Genes that were validated by qPCR,
b
Genes that are annotated as flow model/RPMI/Spider/rat catheter biofilm induced or repressed in CGD.
c
Genes that are Efg1 regulated.