Table 1.
Standardised Hospitalisation Ratios and Absolute Excess Risks of any cerebrovascular event, Cerebral Haemorrhage (ICD10: I61-I62), Cerebral infarction (ICD10: I63, I65-66), Other Cerebrovascular Event (ICD10:I64, I67-I68) by TYA cancer diagnosis, sex, age at diagnosis and decade of diagnosis.
| Any CV Event (ICD10: I60-I68) | Cerebral Haemorrhage (ICD10: I61-I62) | Cerebral infarction (ICD10: I63, I65-I66) | Other CV Event (ICD10: I64, I67-I68)* | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| O | SHR (95% CI) | AER (95% CI) | 1 O | SHR (95% CI) | AER (95% CI) | 1 O | SHR (95% CI) | AER (95% CI) | 1 O | SHR (95% CI) | AER (95% CI) | |
| All Survivors FPN | 2782 | 1.4 (1.3,1.4) | 4.2 (3.6,4.8) | 618 | 2.0 (1.8,2.1) | 1.6 (1.4,1.9) | 1296 | 1.5 (1.4,1.6) | 2.4 (2.0,2.7) | 1114 | 1.4 (1.3,1.5) | 1.7 (1.3,2.0) |
| Breast | 288 | 0.8 (0.7,0.9) | -2.0 (-3.1,-0.8) | 48 | 1.0 (0.7,1.3) | -0.0 (-0.5,0.4) | 127 | 0.9 (0.8,1.1) | -0.4 (-1.1,0.4) | 117 | 0.8 (0.7,1.0) | -1.0 (-1.8,-0.3) |
| Testicular | 278 | 1.0 (0.9,1.1) | 0.1 (-1.3,1.4) | 61 | 1.3 (1.0,1.7) | 0.6 (-0.1,1.2) | 128 | 1.0 (0.8,1.2) | -0.1 (-1.0,0.8) | 97 | 0.9 (0.8,1.2) | -0.2 (-1.0,0.6) |
| Cervix | 317 | 1.2 (1.1,1.4) | 2.4 (0.9,3.8) | 47 | 1.2 (0.9,1.6) | 0.4 (-0.2,0.9) | 137 | 1.4 (1.1,1.6) | 1.5 (0.5,2.4) | 149 | 1.4 (1.2,1.6) | 1.7 (0.7,2.7) |
| Melanoma | 155 | 0.8 (0.7,0.9) | -2.0 (-3.2,-0.8) | 61 | 2.0 (1.5,2.6) | 1.5 (0.7,2.3) | 47 | 0.6 (0.4,0.8) | -1.7 (-2.4,-1.0) | 47 | 0.6 (0.4,0.8) | -1.5 (-2.1,-0.8) |
| CNS tumour | 616 | 4.6 (4.3,5.0) | 33.9 (30.5,37.4) | 183 | 8.3 (7.2,9.6) | 11.2 (9.3,13.0) | 256 | 4.4 (3.9,5.0) | 13.8 (11.6,16.0) | 268 | 5.1 (4.5,5.8) | 15.1 (12.8,17.3) |
| Hodgkin Lymphoma | 228 | 1.6 (1.4,1.8) | 4.8 (3.1,6.6) | 43 | 1.7 (1.3,2.4) | 1.1 (0.3,1.9) | 135 | 2.1 (1.8,2.5) | 4.2 (2.9,5.6) | 76 | 1.4 (1.1,1.7) | 1.2 (0.2,2.2) |
| NHL | 139 | 1.6 (1.4,1.9) | 6.7 (3.8,9.5) | 33 | 2.4 (1.6,3.3) | 2.3 (1.0,3.7) | 70 | 1.8 (1.4,2.3) | 3.9 (1.9,6.0) | 47 | 1.4 (1.0,1.9) | 1.7 (0.1,3.4) |
| Thyroid | 65 | 0.9 (0.7,1.2) | -0.6 (-2.7,1.5) | 9 | 0.8 (0.4,1.6) | -0.2 (-1.0,0.6) | 34 | 1.2 (0.8,1.7) | 0.7 (-0.8,2.3) | 27 | 1.0 (0.6,1.4) | -0.1 (-1.5,1.2) |
| Gastrointestinal | 88 | 0.9 (0.7,1.2) | -1.0 (-3.9,1.9) | 19 | 1.3 (0.8,2.1) | 0.7 (-0.6,2.1) | 43 | 1.0 (0.7,1.4) | 0.1 (-2.0,2.1) | 43 | 1.1 (0.8,1.5) | 0.7 (-1.4,2.7) |
| STS | 84 | 1.3 (1.0,1.6) | 3.4 (0.4,6.5) | 22 | 2.2 (1.4,3.3) | 2.0 (0.5,3.6) | 42 | 1.5 (1.1,2.0) | 2.4 (0.2,4.5) | 36 | 1.4 (1.0,2.0) | 1.8 (-0.2,3.8) |
| Leukaemia | 70 | 2.5 (1.9,3.1) | 10.2 (6.2,14.2) | 26 | 5.2 (3.4,7.6) | 5.1 (2.7,7.6) | 28 | 2.3 (1.5,3.3) | 3.9 (1.3,6.4) | 27 | 2.6 (1.7,3.8) | 4.1 (1.6,6.6) |
| GU (other) | 93 | 1.6 (1.3,1.9) | 8.3 (3.7,12.8) | 22 | 2.5 (1.6,3.8) | 3.2 (1.0,5.4) | 46 | 1.8 (1.3,2.4) | 4.9 (1.7,8.1) | 33 | 1.3 (0.9,1.9) | 2.0 (-0.7,4.7) |
| Ovary | 52 | 1.0 (0.7,1.3) | -0.3 (-3.1,2.5) | 7 | 0.9 (0.4,1.9) | -0.1 (-1.2,0.9) | 23 | 1.1 (0.7,1.6) | 0.4 (-1.5,2.3) | 20 | 0.9 (0.5,1.4) | -0.5 (-2.2,1.2) |
| Bladder | 83 | 1.0 (0.8,1.2) | -0.3 (-4.1,3.5) | 10 | 0.8 (0.4,1.4) | -0.6 (-1.9,0.7) | 47 | 1.2 (0.9,1.6) | 1.5 (-1.4,4.3) | 32 | 0.9 (0.6,1.3) | -0.6 (-2.9,1.8) |
| Head & Neck | 123 | 2.6 (2.2,3.1) | 21.5 (15.4,27.7) | 13 | 1.7 (0.9,3.0) | 1.5 (-0.4,3.5) | 75 | 3.5 (2.8,4.4) | 15.0 (10.2,19.8) | 51 | 2.7 (2.0,3.5) | 8.9 (5.0,12.8) |
| Other | 103 | 1.5 (1.2,1.9) | 5.8 (2.6,9.1) | 14 | 1.3 (0.7,2.2) | 0.6 (-0.6,1.7) | 58 | 2.0 (1.5,2.5) | 4.7 (2.2,7.1) | 44 | 1.6 (1.2,2.2) | 2.8 (0.6,4.9) |
| P-heterogeneity | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | ||||
| Male | 1322 | 1.5 (1.5,1.6) | 6.6 (5.6,7.6) | 322 | 2.2 (2.0,2.5) | 2.5 (2.0,3.0) | 659 | 1.6 (1.5,1.7) | 3.5 (2.8,4.2) | 505 | 1.6 (1.4,1.7) | 2.5 (1.9,3.2) |
| Female | 1460 | 1.3 (1.2,1.3) | 2.7 (2.1,3.4) | 296 | 1.8 (1.6,2.0) | 1.1 (0.8,1.4) | 637 | 1.4 (1.3,1.5) | 1.6 (1.2,2.1) | 609 | 1.3 (1.2,1.4) | 1.1 (0.7,1.6) |
| P-heterogeneity | <0.001 | <0.001 | 0.004 | <0.001 | 0.016 | <0.001 | 0.001 | 0.006 | ||||
| Age at FPN Diagnosis(years) | ||||||||||||
| 15-19 | 148 | 3.6 (3.0,4.2) | 8.9 (6.9,10.9) | 44 | 5.3 (3.8,7.1) | 3.0 (1.9,4.1) | 67 | 4.3 (3.3,5.4) | 4.3 (2.9,5.6) | 56 | 4.1 (3.1,5.4) | 3.5 (2.3,4.8) |
| 20-24 | 219 | 2.0 (1.8,2.3) | 5.2 (3.9,6.6) | 53 | 2.7 (2.0,3.5) | 1.6 (0.9,2.2) | 101 | 2.3 (1.9,2.8) | 2.7 (1.8,3.7) | 81 | 2.2 (1.7,2.7) | 2.1 (1.2,2.9) |
| 25-29 | 407 | 1.6 (1.4,1.7) | 4.2 (3.1,5.4) | 91 | 2.1 (1.7,2.5) | 1.3 (0.8,1.9) | 192 | 1.8 (1.5,2.1) | 2.4 (1.7,3.2) | 164 | 1.7 (1.5,2.0) | 2.0 (1.2,2.7) |
| 30-34 | 722 | 1.3 (1.2,1.4) | 3.6 (2.5,4.6) | 176 | 2.1 (1.8,2.4) | 1.8 (1.3,2.3) | 318 | 1.4 (1.2,1.5) | 1.7 (1.0,2.4) | 255 | 1.2 (1.1,1.4) | 0.8 (0.2,1.5) |
| 35-39 | 1286 | 1.2 (1.2,1.3) | 3.5 (2.4,4.6) | 254 | 1.6 (1.4,1.8) | 1.5 (1.0,2.0) | 618 | 1.3 (1.2,1.4) | 2.3 (1.6,3.1) | 558 | 1.3 (1.2,1.4) | 1.7 (1.0,2.4) |
| P-trend | <0.001 | <0.001 | <0.001 | 0.079 | <0.001 | 0.007 | <0.001 | 0.002 | ||||
| Decade of FPN Diagnosis | ||||||||||||
| 1971-1979 | 809 | 1.1 (1.1,1.2) | 3.9 (1.8,6.0) | 118 | 1.2 (1.0,1.4) | 0.8 (-0.0,1.6) | 404 | 1.2 (1.1,1.4) | 3.0 (1.5,4.5) | 376 | 1.2 (1.1,1.3) | 2.3 (0.8,3.7) |
| 1980-1989 | 1097 | 1.5 (1.4,1.6) | 5.6 (4.6,6.7) | 235 | 2.0 (1.7,2.3) | 1.9 (1.4,2.3) | 519 | 1.6 (1.5,1.8) | 3.2 (2.5,4.0) | 448 | 1.5 (1.4,1.7) | 2.5 (1.8,3.2) |
| 1990-1999 | 700 | 1.6 (1.4,1.7) | 3.4 (2.7,4.2) | 195 | 2.5 (2.1,2.8) | 1.6 (1.2,2.0) | 309 | 1.8 (1.6,2.0) | 1.8 (1.4,2.3) | 239 | 1.5 (1.3,1.7) | 1.1 (0.7,1.5) |
| 2000-2006 | 176 | 1.7 (1.4,1.9) | 3.1 (1.9,4.2) | 70 | 3.7 (2.9,4.7) | 2.2 (1.5,3.0) | 64 | 1.5 (1.1,1.9) | 0.9 (0.2,1.6) | 51 | 1.4 (1.0,1.8) | 0.6 (0.0,1.2) |
| P-trend | <0.001 | <0.001 | <0.001 | 0.089 | <0.001 | <0.001 | 0.007 | <0.001 | ||||
Abbreviations: CV=cerebrovascular; ICD= International classification of disease; O= observed; SHR=standardised hospitalisation ratio; AER=absolute excess risk; CI=confidence interval; FPN=first primary neoplasms; CNS=central nervous system; NHL=non-hodgkin lymphoma; STS=soft-tissue sarcoma; GU=genitourinary.
‘Constituting ICD10: I64-Stroke not specified as haemorrhage or infarction (n=454); I67.0 – Dissection of cerebral arteries, non-ruptured (n=10); I67.1 – Cerebral aneurysm, non-ruptured (n=98); I67.2 – Cerebral atherosclerosis (n=38); I67.4- Hypertensive encephalopathy (n=12); I67.5-I67.8 – Other specified cerebrovascular disease (n=399); I67.9- Cerebrovascular disease, unspecified (n=244); I68 – Cerebrovascular disorders in diseases elsewhere classified (n=3).