Table 4.
SHRs and AERs of any cerebrovascular event, Cerebral infarction (ICD10: I63, I65-66) or Other Cerebrovascular Event (ICD10: I67-I68) among survivors of head and neck tumours by sex, age at diagnosis, decade of diagnosis and attained age
| Any CV Event (ICD10: I60-I68) | Cerebral infarction (ICD10: I63, I65-66) | Other CV Event (ICD10: I64, I67-I68) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| O | SHR (95%CI) | AER (95%CI) | O | SHR (95%CI) | AER (95%CI) | O | SHR (95%CI) | AER (95%CI) | |
| All HN tumours | 123 | 2.6 (2.2,3.1) | 21.5 (15.4,27.7) | 75 | 3.5 (2.8,4.4) | 15.0 (10.2,19.8) | 51 | 2.7 (2.0,3.5) | 8.9 (5.0,12.8) |
| Sex | |||||||||
| Male | 91 | 2.9 (2.3,3.6) | 30.4 (20.9,39.9) | 58 | 3.8 (2.9,4.9) | 21.5 (14.0,29.0) | 36 | 2.9 (2.0,4.0) | 11.7 (5.8,17.5) |
| Female | 32 | 2.1 (1.4,2.9) | 10.5 (3.5,17.6) | 17 | 2.8 (1.6,4.4) | 6.9 (1.8,12.0) | 15 | 2.3 (1.3,3.8) | 5.4 (0.6,10.2) |
| p-heterogeneity | 0.098 | 0.002 | 0.258 | 0.001 | 0.494 | 0.027 | |||
| Age at FPN Diagnosis (years) | |||||||||
| 15-24 | 12 | 4.6 (2.4,8.0) | 16.0 (4.4,27.6) | 8 | 7.8 (3.3,15.3) | 11.9 (2.4,21.3) | * | * | * |
| 25-29 | 14 | 2.6 (1.4,4.3) | 13.5 (1.9,25.2) | 8 | 3.3 (1.4,6.5) | 8.8 (0.1,17.5) | 8 | 3.9 (1.7,7.6) | 9.4 (0.6,18.1) |
| 30-34 | 31 | 2.5 (1.7,3.6) | 20.4 (8.6,32.3) | 18 | 3.2 (1.9,5.1) | 13.5 (4.5,22.4) | 13 | 2.7 (1.4,4.5) | 8.7 (1.1,16.3) |
| 35-39 | 66 | 2.5 (1.9,3.2) | 28.1 (16.8,39.4) | 41 | 3.3 (2.4,4.5) | 20.1 (11.3,28.9) | 27 | 2.4 (1.6,3.5) | 11.0 (3.9,18.1) |
| p-trend | 0.152 | 0.053 | 0.116 | 0.106 | 0.288 | 0.096 | |||
| Decade of FPN Diagnosis | |||||||||
| 1971-1979 | 35 | 1.8 (1.3,2.5) | 25.5 (6.8,44.2) | 19 | 2.0 (1.2,3.2) | 15.2 (1.7,28.8) | 19 | 2.2 (1.3,3.4) | 16.1 (2.7,29.6) |
| 1980-1989 | 40 | 2.5 (1.8,3.4) | 21.0 (10.1,31.9) | 25 | 3.4 (2.2,5.1) | 15.5 (6.9,24.0) | 18 | 2.8 (1.7,4.5) | 10.1 (2.9,17.3) |
| 1990-2006 | 48 | 4.2 (3.1,5.6) | 20.5 (12.9,28.1) | 31 | 6.5 (4.4,9.2) | 14.6 (8.5,20.7) | 14 | 3.5 (1.9,5.9) | 5.6 (1.5,9.7) |
| p-trend | <0.001 | 0.799 | <0.001 | 0.991 | 0.158 | 0.119 | |||
| Attained Age (years) | |||||||||
| 20-44 | 23 | 4.6 (2.9,6.8) | 13.2 (6.3,20.1) | 15 | 8.6 (4.8,14.2) | 9.7 (4.2,15.3) | 6 | 3.7(1.4,8.1) | 3.2 (-0.3,6.7) |
| 44-49 | 22 | 3.8 (2.4,5.7) | 22.6 (9.7,35.4) | 14 | 6.2 (3.4,10.4) | 16.3 (6.1,26.5) | 7 | 3.4(1.4,7.1) | 6.9 (-0.3,14.0) |
| 50-54 | 23 | 3.2 (2.1,4.9) | 28.6 (11.7,45.5) | 16 | 5.4 (3.1,8.7) | 23.3 (9.3,37.3) | 8 | 3.0 (1.3,6.0) | 9.5 (-0.3,19.4) |
| 54-59 | 18 | 2.3 (1.3,3.6) | 24.5 (4.3,44.7) | 10 | 2.7 (1.3,5.0) | 15.3 (0.4,30.2) | 7 | 2.3 (0.9,4.7) | 9.3 (-3.0,21.7) |
| 60+ | 37 | 1.8 (1.3,2.5) | 32.7 (8.8,56.5) | 20 | 1.8 (1.1,2.9) | 17.9 (0.8,35.0) | 23 | 2.4 (1.5,3.6) | 25.7 (7.5,43.9) |
| p-trend | <0.001 | 0.029 | <0.001 | 0.159 | 0.215 | 0.002 | |||
Abbreviations: CV=cerebrovascular; ICD= International classification of disease; O= observed; SHR=standardised hospitalisation ratio; AER=absolute excess risk; CI=confidence interval; FPN=first primary neoplasms; CNS=central nervous system; NHL=non-Hodgkin lymphoma; STS=soft-tissue sarcoma; GU=genitourinary.
*
Omitted from table due to few events (less than 5 observed).